Topical tretinoin is a prescription retinoid or Vitamin A derivative treatment that is FDA approved for the treatment of Acne vulgaris and Photodamaged skin.
Although tretinoin has been in use over the decades with many clinical studies supporting it, the exact mechanism remains unknown.
Topical tretinoin, a first generation retinoid, effectively treats acne by reducing the build up of skin cells within the hair follicles and cohesiveness of keratinocytes. Thus, it decreases comedomes (whiteheads and blackheads) and congestion within your hair follicles.
From research, topical tretinoin has shown to potently enhance epidermal thickening though keratinocytes proliferation. Keratinocytes are the predominant cells found in the epidermis of the skin. A reduction of melanocytic activity from topical tretinoin may explain the improvement of skin hyperpigmentation either as a result of acne or photodamaged skin. In the dermis, tretinoin induces formation of new collagen and blood vessel formation.
These functional and structural changes of topical tretinoin not only improves atrophic acne scars but also improve skin hyerpigmentation, wrinkles and skin roughness.
The most common side effects of topical retinoids include dryness, redness, itchiness and peeling. These initial retinoid effects are common and usually fade after a few weeks of application. It is also common for acne to worsen during the start of your treatment, but again this effect fades over time.
There are various doses of topical tretinoin available; 0.01%, 0.025% and 0.5% strengths are commonly prescribed.
A small amount is to be applied lightly to the affected areas in the evening. It may be helpful to apply a moisturizer after the application of the topical retinoids to reduce skin irritation.
You may observe your acne starting to improve as soon as 2-3 weeks. However, it may take more than 6 weeks of treatment to see consistent benefits from your topical retinoid use.
Topical tretinoin effectively reduces your wrinkles, hyperpigmentation and skin roughness from photo damaged skin from about 6-12 months.
Dr. Moses Ng is a distinguished professional in the field of aesthetic medicine, renowned for his expertise in advanced cosmetic procedures. With over 15 years of experience, extensive training and a keen eye for detail, Dr. Ng specializes in a wide range of treatments, including injectables, laser therapies, and acne scar management.
Dr. Moses Ng’s commitment to excellence and patient-centric approach have earned him a reputation as a trusted clinician in aesthetic medicine. His continuous pursuit of the latest advancements in the field ensures that his patients receive the highest standard of care and the most effective treatments available.
