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Melasma Treatment

melasma treatment singapore
Table of Contents

Do you have persistent brown or grey-brown patches on your cheeks, forehead, upper lip or chin that seem to darken with sun exposure? You may be experiencing melasma, a common pigmentation condition caused by excess melanin production in the skin.

Melasma can be challenging to treat because it is often influenced by multiple factors, including sun exposure, hormones, genetics and skin inflammation. While the condition is not harmful, it can significantly affect confidence and quality of life.

At APAX Medical & Aesthetics Clinic, we provide personalised melasma treatment plans tailored to your skin type, pigmentation depth and underlying triggers. Depending on your skin condition, treatment may involve prescription topical medications, oral therapies, chemical peels, pigment lasers or combination approaches designed to reduce pigmentation safely while minimising the risk of recurrence.

Our goal is not simply to lighten existing pigmentation, but to help you achieve clearer, more even-toned skin with natural-looking and sustainable results.

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Melasma Singapore
Melasma is a common pigmentation disorder that causes symmetrical brown or grey-brown patches to develop on sun-exposed areas of the face.

What is Melasma?

Melasma is a common form of facial hyperpigmentation that causes brown, grey-brown or tan patches to develop on sun-exposed areas of the skin [1]. It most commonly affects the cheeks, forehead, nose, upper lip and chin, particularly in women and individuals with darker skin types.

Although melasma is not harmful, it can be challenging to treat and often tends to recur without proper management. Effective melasma treatment involves identifying and reducing trigger factors, protecting the skin from ultraviolet (UV) and visible light exposure, and using targeted treatments to control pigmentation while minimising the risk of relapse.

What Does Melasma Look Like?

Melasma typically appears as flat, symmetrical patches of brown, grey-brown or tan pigmentation on sun-exposed areas of the face. The pigmentation most commonly develops on the cheeks, forehead, nose, upper lip and jawline, often with irregular or poorly defined borders.

Many individuals with melasma may also have other forms of pigmentation or age-related skin changes occurring at the same time. These can include:

  • Freckles — Small, flat brown spots that become more noticeable with sun exposure.
  • Solar lentigines (sun spots)  — Well-defined areas of pigmentation that develop due to cumulative sun damage over time.
  • Seborrhoeic keratoses — Benign, raised growths that may appear brown, black or tan in colour.
  • Skin tags — Small, soft, harmless skin growths that commonly develop in areas of friction.

Because several pigmentation conditions can appear similar, a professional assessment is important to determine whether pigmentation is caused by melasma alone or occurs alongside other skin concerns that may require different treatment approaches.

Melasma Appearance Singapore
Melasma typically appears as symmetrical brown or grey-brown patches on the cheeks, forehead, nose or upper lip, creating uneven facial pigmentation with irregular borders.

What Causes Melasma?

The exact cause of melasma is not fully understood. However, research suggests that the condition develops through a combination of genetic, hormonal and environmental factors that stimulate excess melanin production in the skin.

Common triggers and contributing factors include:

  • Sun exposure and visible light — Ultraviolet (UV) radiation and visible light can stimulate pigment-producing cells, leading to darkening of existing melasma and the development of new pigmentation [2].
  • Hormonal changes — Hormonal fluctuations during pregnancy, the use of oral contraceptive pills and hormone replacement therapy are well-recognised triggers for melasma [3]. This is why melasma is sometimes referred to as the "mask of pregnancy".
  • Genetic predisposition — Individuals with a family history of melasma may have a higher risk of developing the condition, particularly those with darker skin types and Asian skin [4].
  • Skin inflammation and irritation — Certain skincare products, cosmetic procedures or inflammatory skin conditions may worsen pigmentation in susceptible individuals [5].
  • Oxidative stress and vascular factorsEmerging evidence suggests that oxidative stress, inflammation and changes in the skin's blood vessels may contribute to the development and persistence of melasma [6].

Because melasma is often influenced by multiple factors simultaneously, successful treatment usually requires a comprehensive management plan that combines trigger avoidance, sun protection and targeted pigmentation treatments.

What are the Different Types of Melasma?

Melasma can affect different layers of the skin. Identifying the type of melasma is an important part of the consultation process, as it helps determine the most appropriate treatment approach and expected response to treatment.

Epidermal Vs. Dermal Melasma Singapore
Epidermal melasma affects the upper layers of the skin and appears more defined, while dermal melasma involves deeper pigmentation that often appears more diffuse and can be more challenging to treat.
  • Epidermal melasma — Pigment is located primarily within the epidermis, the outermost layer of the skin. This type typically appears more defined and may respond more readily to topical treatments, chemical peels and selected laser procedures.
  • Dermal melasma — Pigment is deposited deeper within the dermis. Dermal melasma is often more difficult to treat and may require a combination of treatment modalities to achieve noticeable improvement [7].
  • Mixed melasma — Pigmentation is present in both the epidermis and dermis. This is the most common type of melasma and often benefits from a personalised combination treatment approach.

How is Melasma Diagnosed?

Melasma is primarily diagnosed through a detailed consultation and clinical examination of the skin. During the assessment, your doctor will evaluate the appearance, distribution and pattern of pigmentation, as well as discuss potential contributing factors such as sun exposure, hormonal changes, medications and family history.

Additional diagnostic tools may be used to assess the depth and severity of pigmentation:

  • Wood’s lamp examination — A Wood’s lamp uses specialised light to evaluate the depth of pigmentation within the skin [8]. This can help differentiate between epidermal, dermal and mixed melasma, while also identifying other pigmentation concerns such as freckles and sun spots.
  • Melasma severity assessment — The extent and severity of melasma may be assessed using clinical scoring systems such as the Melasma Area and Severity Index (MASI) [9]. Factors such as the area involved, pigmentation intensity and uniformity of pigmentation are taken into consideration. Clinical photography is often used to monitor treatment progress over time.

Because other pigmentation disorders can resemble melasma, an accurate diagnosis is important to ensure the most appropriate treatment strategy is selected.

Melasma Area and Severity Index (MASI) Singapore
The Melasma Area and Severity Index (MASI) is a clinical scoring system used to assess the extent, distribution and severity of melasma and monitor treatment response over time.

What Happens During a Melasma Consultation?

A melasma consultation involves a detailed assessment of your skin, pigmentation pattern and potential contributing factors. Because melasma can vary significantly between individuals, an accurate diagnosis is important to determine the most appropriate treatment approach.

During the consultation, Dr. NG will review your medical history, current skincare routine, previous treatments and any factors that may contribute to pigmentation, such as sun exposure, pregnancy, hormonal changes or medications. A clinical examination of the skin will then be performed to assess the distribution, severity and depth of pigmentation.

Additional assessments, such as a Wood’s lamp examination, may be used to determine whether the melasma is primarily epidermal, dermal or mixed. Based on the findings, a personalised treatment plan will be developed, which may include topical medications, oral therapies, laser treatments, microneedling or a combination approach tailored to your skin type and treatment goals.

How is Melasma Treated?

Melasma is a chronic pigmentation disorder that often requires long-term management. Because multiple factors contribute to its development, no single treatment is suitable for every individual. The most effective treatment plans typically combine trigger avoidance, sun protection and targeted medical treatments.

Treatment recommendations are personalised according to the severity of pigmentation, the depth of melasma, skin type and individual treatment goals.

Sun Protection and Prevention

Daily sun protection is one of the most important components of melasma management.

  • Broad-spectrum sunscreen — Regular use of a broad-spectrum sunscreen with SPF 30–50 and high UVA protection helps reduce UV-induced pigmentation and minimise recurrence.
  • Protection from visible light — Visible light may also contribute to melasma. Additional protection such as hats, umbrellas and tinted sunscreens may be beneficial.
  • Avoiding known triggers — Limiting excessive sun exposure and addressing hormonal or inflammatory triggers where possible may help reduce worsening of pigmentation.
  • Cosmetic camouflage — Medical-grade tinted sunscreens and cosmetic products may help conceal pigmentation while treatment is ongoing.

Topical Treatments for Melasma

Topical medications are often considered a primary treatment for melasma. These treatments work by reducing melanin production, accelerating skin cell turnover and controlling inflammation within the skin.

Common topical treatment options include:

  • Triple combination therapy — A combination of hydroquinone, tretinoin and a mild corticosteroid remains one of the most effective topical treatment approaches for melasma [10]. This combination helps reduce pigment production, promote the removal of pigmented skin cells and control inflammation.
  • Hydroquinone — A skin-lightening agent that inhibits melanin production and helps reduce pigmentation [11].
  • Tretinoin (Vitamin A derivative) Increases skin cell turnover and supports the elimination of excess pigment [12].
  • Azelaic acidHelps reduce pigmentation while offering anti-inflammatory benefits [13].
  • Tranexamic acid — Available in topical formulations to help reduce pigment formation [14].
  • Kojic acid, niacinamide and vitamin C — May be used as adjunctive treatments to support overall pigmentation management.

Your doctor will recommend a customised topical treatment regimen based on your skin type and the severity of your melasma.

Oral Medications for Melasma

Oral therapy may be considered in selected patients, particularly when topical treatments alone are insufficient.

  • Oral tranexamic acid — Tranexamic acid is one of the most extensively studied oral treatments for melasma. It works by reducing pathways involved in melanin production and may enhance the effectiveness of topical treatments [15]. While many patients experience noticeable improvement, maintenance treatment and ongoing sun protection remain important because recurrence can occur after treatment is discontinued.

Other oral supplements that have been investigated for melasma management include:

  • Carotenoids and glutathioneAntioxidant supplements that have been studied for their potential role in pigmentation management [18].

Suitability for oral treatments should be determined during consultation, as certain medications may not be appropriate for all individuals.

Laser Treatment for Melasma

Laser treatment may be considered as part of a comprehensive melasma management plan, particularly for patients who do not achieve sufficient improvement with topical and oral therapies.

Non-ablative laser technologies, including Q-switched and picosecond lasers, are commonly used because they selectively target pigment while minimising damage to surrounding skin. These treatments are generally better suited for individuals with darker skin types compared to more aggressive laser procedures.

However, laser treatment should not be viewed as a standalone solution for melasma. Because melasma is a complex condition influenced by hormonal, genetic and inflammatory factors, pigmentation may recur even after successful laser treatment.

Potential risks include:

  • Post-inflammatory hyperpigmentation — Temporary darkening of the treated area.
  • Hypopigmentation — Lightening of the skin in treated areas.
  • Recurrence of melasma — Pigmentation may return if underlying triggers remain present.

For this reason, laser treatments are often combined with topical medications, oral therapy and ongoing sun protection for optimal long-term results.

Laser Treatment for Melasma Singapore
Laser treatment can help reduce melasma by targeting excess pigment in the skin, improving pigmentation and promoting a more even skin tone when used as part of a comprehensive treatment plan.

Microneedling for Melasma

Microneedling is an emerging treatment option that may help improve melasma by creating controlled microchannels within the skin [19]. These channels can enhance the penetration of topical medications while stimulating natural skin renewal processes.

Potential benefits of microneedling include:

  • Improved delivery of topical treatments — Allows active ingredients to penetrate more effectively into the skin.
  • Enhanced skin renewal — Supports collagen production and may assist in the gradual elimination of excess pigment.
  • Combination treatment potential — Can be performed alongside selected depigmenting agents and other pigmentation therapies.

While early studies have shown promising results, response to treatment can vary between individuals, and further research is ongoing to establish its role in routine melasma management.

Why Does Melasma Keep Coming Back?

Melasma is considered a chronic pigmentation disorder, which means that even after successful treatment, the condition may recur over time. This is because the underlying factors that contribute to melasma, such as sun exposure, hormonal influences, genetics and skin inflammation, may continue to affect pigment production.

Ultraviolet (UV) radiation and visible light are among the most common triggers for recurrence. Even brief periods of sun exposure can stimulate pigment-producing cells and cause previously treated areas to darken again. Hormonal fluctuations related to pregnancy, oral contraceptive pills or hormone replacement therapy may also contribute to relapse.

Although melasma cannot always be permanently cured, appropriate treatment and long-term maintenance can help keep pigmentation under control. Consistent sun protection, trigger avoidance and ongoing skincare are often essential components of successful long-term management.

How Long Does Melasma Treatment Take?

Melasma treatment requires patience, as improvement is usually gradual rather than immediate. The time required to see results varies depending on the severity of pigmentation, the depth of melasma, individual skin characteristics and the treatment methods used.

Many patients begin to notice improvement within several weeks of starting topical therapy, while more significant results may take several months to develop. Individuals undergoing laser treatments or combination therapy may require multiple treatment sessions spaced several weeks apart to achieve optimal outcomes.

Because melasma is a chronic condition, treatment does not necessarily end once pigmentation improves. Maintenance therapy and ongoing sun protection are often recommended to help preserve results and reduce the risk of recurrence.

What Results Can I Expect From Melasma Treatment?

The goal of melasma treatment is to reduce the appearance of pigmentation, improve overall skin clarity and achieve a more even skin tone. While most patients experience noticeable improvement with appropriate treatment, the degree of improvement can vary depending on factors such as pigmentation depth, skin type and underlying triggers.

Potential outcomes of melasma treatment include:

  • Lighter pigmentation — Reduction in the intensity and visibility of brown or grey-brown patches.
  • More even skin tone — Improved skin clarity and a more uniform complexion.
  • Reduced risk of worsening pigmentation — Ongoing treatment and sun protection can help minimise future flare-ups.
  • Improved confidence and quality of life — Many individuals feel more comfortable and confident once visible pigmentation is reduced.

It is important to understand that melasma often requires long-term management. While treatment can significantly improve pigmentation, maintenance therapy may be necessary to sustain results and minimise recurrence over time.

Summary

Melasma is a common pigmentation disorder that causes brown or grey-brown patches to develop on sun-exposed areas of the face. While the exact cause is not fully understood, factors such as sun exposure, hormonal changes, genetics and skin inflammation are known to contribute to its development. 

Because melasma can affect different layers of the skin and varies from person to person, accurate diagnosis is essential for selecting the most appropriate treatment approach. Although melasma can be persistent and prone to recurrence, a personalised treatment plan can help significantly reduce pigmentation and improve overall skin clarity. 

Depending on your skin type and the severity of your condition, treatment may involve topical medications, oral therapies, laser treatments, microneedling or a combination of approaches. 

If you are concerned about persistent facial pigmentation or would like to explore suitable treatment options, schedule a consultation with APAX Medical & Aesthetics Clinic for a comprehensive assessment and personalised melasma treatment plan.

Frequently Asked Questions (FAQs) 

Is melasma harmful to my health?

Melasma is a benign skin condition and does not increase the risk of skin cancer or other serious health problems. However, the pigmentation can be cosmetically bothersome and may affect confidence and emotional wellbeing.

Can men develop melasma?

Yes. Although melasma is more common in women, men can also develop the condition. Risk factors such as sun exposure, genetics and darker skin types may contribute to melasma in male patients.

Does makeup make melasma worse?

Most makeup products do not worsen melasma when used appropriately. In fact, tinted sunscreens and cosmetic camouflage products can help conceal pigmentation while providing additional protection against visible light.

Can melasma develop after pregnancy?

Yes. Hormonal changes during pregnancy are a well-recognised trigger for melasma, which is why the condition is sometimes referred to as the “mask of pregnancy.” While pigmentation may improve after childbirth, some cases can persist without treatment.

Should I stop using over-the-counter whitening products?

Not all pigmentation products are suitable for melasma, and some may cause skin irritation that can worsen pigmentation. It is advisable to seek professional advice before starting or continuing skin-lightening treatments.

Can lifestyle habits affect melasma?

Yes. Frequent sun exposure, inadequate sun protection and certain hormonal factors may contribute to worsening pigmentation. Consistent skincare and sun protection play an important role in long-term melasma management.

Is melasma treatment suitable for darker skin types?

Yes. Melasma commonly affects individuals with darker skin tones, and treatment plans can be tailored according to skin type. A professional assessment is important to select treatment options that minimise the risk of unwanted pigmentation changes.

When should I see a doctor for facial pigmentation?

You should consider seeking medical advice if facial pigmentation is becoming more noticeable, affecting your confidence, changing in appearance or not responding to skincare products. An assessment can help determine whether the pigmentation is caused by melasma or another skin condition requiring different treatment.

References 

  1. Sathe, N. C., & Launico, M. V. (2026). Melasma. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK459271/ 
  2. Liu, W., Chen, Q., & Xia, Y. (2023). New mechanistic insights of melasma. Clinical, Cosmetic and Investigational Dermatology, 16, 429–442. https://doi.org/10.2147/CCID.S396272 
  3. Kania, B., Lolis, M., & Goldberg, D. (2025). Melasma management: A comprehensive review of treatment strategies including btx‐a. Journal of Cosmetic Dermatology, 24(2), e16669. https://doi.org/10.1111/jocd.16669 
  4. Wu, M. X., Antony, R., & Mayrovitz, H. N. (n.d.). Melasma: A condition of asian skin. Cureus, 13(4), e14398. https://doi.org/10.7759/cureus.14398 
  5. Davis, E. C., & Callender, V. D. (2010). Postinflammatory hyperpigmentation: A review of the epidemiology, clinical features, and treatment options in skin of color. The Journal of Clinical and Aesthetic Dermatology, 3(7), 20–31. 
  6. Ali, L., & Al Niaimi, F. (2025). Pathogenesis of melasma explained. International Journal of Dermatology, 64(7), 1201–1212. https://doi.org/10.1111/ijd.17718 
  7. Ghasemiyeh, P., Fazlinejad, R., Kiafar, M. R., Rasekh, S., Mokhtarzadegan, M., & Mohammadi-Samani, S. (2024). Different therapeutic approaches in melasma: Advances and limitations. Frontiers in Pharmacology, 15, 1337282. https://doi.org/10.3389/fphar.2024.1337282 
  8. Al Aboud, D. M., & Gossman, W. (2026). Wood’s Light. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK537193/ 
  9. Majid, I., Haq, I., Imran, S., Keen, A., Aziz, K., & Arif, T. (2016). Proposing melasma severity index: A new, more practical, office-based scoring system for assessing the severity of melasma. Indian Journal of Dermatology, 61(1), 39–44. https://doi.org/10.4103/0019-5154.174024 
  10. González-Molina, V., Martí-Pineda, A., & González, N. (2022). Topical treatments for melasma and their mechanism of action. The Journal of Clinical and Aesthetic Dermatology, 15(5), 19–28. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC9122278/ 
  11. Schwartz, C., Jan, A., & Zito, P. M. (2026). Hydroquinone. In StatPearls. StatPearls Publishing. http://www.ncbi.nlm.nih.gov/books/NBK539693/ 
  12. Zasada, M., & Budzisz, E. (2019). Retinoids: Active molecules influencing skin structure formation in cosmetic and dermatological treatments. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 36(4), 392–397. https://doi.org/10.5114/ada.2019.87443 
  13. Sauer, N., Oślizło, M., Brzostek, M., Wolska, J., Lubaszka, K., & Karłowicz-Bodalska, K. (2023). The multiple uses of azelaic acid in dermatology: Mechanism of action, preparations, and potential therapeutic applications. Advances in Dermatology and Allergology/Postȩpy Dermatologii i Alergologii, 40(6), 716–724. https://doi.org/10.5114/ada.2023.133955 
  14. AlJabr, A., AlAnazi, A. M. I., & AlEtebi, R. A. A. (2026). Tranexamic acid for hyperpigmentation disorders: A literature review on efficacy and safety in melasma and pih. Journal of Cosmetic Dermatology, 25(2), e70692. https://doi.org/10.1111/jocd.70692 
  15. Godse, K., Sarkar, R., Mysore, V., Shenoy, M. M., Chatterjee, M., Damisetty, R., Shah, S., Vedamurthy, M., Aurangabadkar, S., Srinivas, C., Ganjoo, A., Das, S., & Patil, A. (2023). Oral tranexamic acid for the treatment of melasma: Evidence and experience-based consensus statement from indian experts. Indian Journal of Dermatology, 68(2), 178–185. https://doi.org/10.4103/ijd.ijd_266_22 
  16. Ni, Z., Mu, Y., & Gulati, O. (2002). Treatment of melasma with Pycnogenol. Phytotherapy Research: PTR, 16(6), 567–571. https://doi.org/10.1002/ptr.1085 
  17. Nestor, M., Bucay, V., Callender, V., Cohen, J. L., Sadick, N., & Waldorf, H. (2014). Polypodium leucotomos as an adjunct treatment of pigmentary disorders. The Journal of Clinical and Aesthetic Dermatology, 7(3), 13–17. https://www.ncbi.nlm.nih.gov/pmc/articles/PMC3970827/ 
  18. Shanaida, M., Mykhailenko, O., Lysiuk, R., Hudz, N., Balwierz, R., Shulhai, A., Shapovalova, N., Shanaida, V., & Bjørklund, G. (2025). Carotenoids for antiaging: Nutraceutical, pharmaceutical, and cosmeceutical applications. Pharmaceuticals (Basel, Switzerland), 18(3), 403. https://doi.org/10.3390/ph18030403 
  19. Chen, W., Jian, X., & Yu, B. (2025). Review of applications of microneedling in melasma. Journal of Cosmetic Dermatology, 24(1), e16707. https://doi.org/10.1111/jocd.16707   

About Dr Moses Ng

MBBS (London) with distinction
Dip Practical Dermatology (Cardiff) with distinction
Member of American Acne & Rosacea Society
Fellow of American Society for Laser Medicine & Surgery

Dr. Moses Ng is a distinguished professional in the field of aesthetic medicine, renowned for his expertise in advanced cosmetic procedures. With over 15 years of experience, extensive training and a keen eye for detail, Dr. Ng specializes in a wide range of treatments, including injectables, laser therapies, and acne scar management.

Dr. Moses Ng’s commitment to excellence and patient-centric approach have earned him a reputation as a trusted clinician in aesthetic medicine. His continuous pursuit of the latest advancements in the field ensures that his patients receive the highest standard of care and the most effective treatments available.

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    Dr Moses Ng

    MBBS (UK)
    Postgraduate Diploma in Practical Dermatology (UK)
    Roxburg and Henry Silverman Prize in Dermatology (UK)
    Accreditations by Aesthetic Dermatology Educational Group

    Delivering Services Built on Integrity, Empathy and Treatments Affordably Priced for Everyone.

    This article has been medically reviewed by Dr. Moses Ng

    Dr Ng’s main clinical interest lies in Acne & Acne Scar Management, Pigmentation Disorders, and Laser Surgery. He has helped more than 20,000 patients for the past 15 years.
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