profhilo treatment singapore

Profhilo Treatment Singapore

Treats skin laxity and deeply hydrates your skin from within.

Profhilo treatment uses a hybrid hyaluronic acid complex to boost collagen, elastin with long lasting dermal remodeling.

profhilo treatment singapore
Original Profhilo

Table of Contents

What is Profhilo?

hydrated skin after profhilo treatment

The first of its kind, Profhilo® is a revolutionary ‘beneath the skin’ hyaluronic acid moisturising treatment, made with the patented NAHYCO® technology. This results in a unique hyaluronic acid injectable gel, which has a extended stimulating activity on the dermal cells. When injected into skin, Profhilo® stimulates the skin cell receptors to counteract skin laxity and improve and restore firmness of the skin.

One of the highest concentrations of hyaluronic acid on the market, Profhilo® not only boosts and hydrates the skin, but also remodels ageing and sagging tissue. The most common areas of treatment include the face and neck and can also be used for the décolletage, hands, arms, knees and abdomen area where it would effectively treat skin laxity. The treatment is suitable for men and women as well as offering skin benefits for patients of all ages.

Treatment Areas

Face, Neck, Décolletage, Hands, Acne Scars


45 minutes including preparation




Every 6-9 months for maintenance


Profhilo singapore

Regain youthful skin with Profhilo treatment. Aged and damaged skin having weaker self-regenerative capabilities leads to increase in wrinkling, loss of skin elasticity and dehydration. Profhilo reverses the signs of ageing by inducing collagen and hydrating skin from deep within. As an experienced clinician and expert injector, Dr. Ng makes it his mission to deliver the best results to strengthen and restore your skin. 

What are the benefits of Profhilo?

Profhilo offers several benefits as a skin rejuvenation treatment:

  1. Deep Hydration: Profhilo contains high concentrations of hyaluronic acid, which attracts and retains moisture in the skin, providing deep hydration. This helps to improve skin texture, suppleness, and overall hydration levels.

  2. Stimulates Collagen and Elastin Production: Profhilo stimulates the production of collagen and elastin, two proteins essential for maintaining skin elasticity and firmness. As collagen and elastin levels increase, the skin becomes firmer, smoother, and more youthful-looking.

  3. Natural-Looking Results: Unlike some other injectable treatments, Profhilo enhances the skin’s natural beauty without adding volume or altering facial contours dramatically. The result is a subtle yet noticeable improvement in skin quality that looks natural and refreshed.

  4. Addresses Multiple Concerns: Profhilo can target various signs of aging, including fine lines, wrinkles, dullness, and loss of skin elasticity. It can be used on the face, neck, décolletage, hands, and other areas where skin quality has been compromised.

  5. Minimally Invasive: Profhilo is a minimally invasive treatment that involves a series of injections into the skin. There is minimal downtime associated with the procedure, and most people can resume their normal activities immediately afterward.

  6. Long-Lasting Results: While Profhilo is not a permanent treatment, its effects can last for several months. Many people notice improvements in skin hydration, firmness, and texture for up to six to twelve months after treatment, depending on individual factors such as skin type and lifestyle.

  7. Versatility: Profhilo is suitable for a wide range of skin types and ages. It can be used as a standalone treatment or in combination with other cosmetic procedures to enhance overall results.

  8. Safe and Well-Tolerated: Profhilo is generally considered safe when administered by a qualified and experienced practitioner. Side effects are usually mild and temporary, including redness, swelling, bruising, or tenderness at the injection sites. These typically resolve within a few days.

What is the technology behind Profhilo?

Porfhilo uses patented NAHYCO technology hybrid process that combines High and Low molecular weight hyaluronic acid (HA) complexes in 3 phases. These processes result in a stable, long-lasting HA gel with a high concentration.

Phase 1: 32mg High molecular weight HA (1100-1400 KDa) is combined with 32mg Low molecular weight HA (80-110 KDa)

Phase 2: Through a thermal process, hydrogen bonds are broken which allow the chains of the high and low molecular weight HA to unite.

Phase 3: During the cooling process, a newly stabilised hybrid cooperative complex is formed. This stable and long-lasting HA can resists hyaluronidase (an enzyme that breaks down HA) for a longer duration. Profhilo HAs can remain in the skin for about 28days.

profhilo nahyco technology
NAHYCO technology

What makes Profhilo Unique?

There are noteworthy characteristics that make Profhilo treatment different from other HAs in the market. These include:

  • High concentration of hyaluronic acid (64mg/2mls).
  • Natural structure that is thermally stabilized.
  • Duration in skin is comparable to that of low cross-linked gel.
  • No BDDE (1,4-butanediol diglycidyl) or other chemical cross-linked agents added.
profhilo face treatment
profhilo neck treatment

How does Profhilo work?

During Profhilo treatment, the HA is injected into specific areas of the skin. This allows optimal and homogenoues diffusion into the epidermal, dermal and subcutaneous compartments of the skin. The high cohesivity index of the HA during Profhilo treament ensures that it is integrated well within skin tissues.

The low molecular weight HAs attracts water and hydrates the skin, providing the Hydro effect. On the other hand, the high molecular weight HA volumizes the skin by providing a stable dermal scaffold, the lifting effect. This hybrid HA therefore creates a Hydro-lifting action on the skin.

Once the HA is integrated within the skin, it promotes extracellular bioremodelling, stimulates 4 types of skin collagen (type I,III,IV and VII)  and elastin. The supportive role of the hybrid HA complex maintains viability of skin cells (e.g. keratinocytes in the epidermis, fibroblasts in the dermis and adipocytes in the fat layer) This increased elasticity and hydration of the skin layers creates a lifting effect.

Differences between Profhilo and Skin boosters

HA Concentration
Injection Points
Elastin Stimulation
Treatment Interval
Non-crossed link HA
5 per side
First 2 sessions one month apart, then every 6-9 months.
Restylane Skin Bosters
Cross-link HA
First 3 sessions one month apart, then every 6-9 months.
Juvederm Volite
Cross-link HA
Every 6-9 months
Teoxane Redensity
Non-crossed link
3 sessions at 3 weekly interval, then every 4-6 months
Revanesse Pure
Non-crossed link
First 3 sessions one month apart, then every 6-9 months.

Is Profhilo a Filler or Skinbooster?

Profhilo treatment is considered a bioremodelling therapy. This unique stabilized hybrid cooperative HA complex has different biological properties when compared to monotherapy with either High or Low molecular weight HAs. The resistance to enzymatic degradation, slow release action and biocompatibility properties makes it different from the standard HAs in today’s market. In addition, it cannot be considered a skin booster as it has a tightening/ lifting effect on skin tissues.

The slow release action of Profhilo treatment provides hydration at the epidermal layer and enhances volume within the dermal architecture. There is an up-regulation of the 4 main types of collagen. There is an increased expression of type I and III collagen in fibroblasts and type IV and VII in keratinocytes. In addition, elastin and natural HAs within the skin are stimulated. This multimodal effect increases hydration, elasticity and lifting effect of the skin.

Profhilo Treatment Experience

  1. Consultation: Your first step would likely involve a consultation with your doctor. During this consultation, you can discuss your concerns, goals, and medical history to determine if Profhilo is the right treatment for you.

  2. Preparation: On the day of your treatment, the area to be treated will be cleansed thoroughly. We apply a topical anaesthetic cream to minimize discomfort during the injections.

  3. Injection: Profhilo is injected into specific points of the face or other treatment areas using a fine needle. The injections are typically quick and relatively painless. Depending on your needs and goals, multiple injection points may be used.

  4. Post-treatment care: After the injections, you might experience some redness, swelling, or tenderness at the injection sites. These side effects are usually mild and temporary, resolving within a few hours to a couple of days. Your are recommend to avoid strenuous exercise, excessive sun exposure, or certain skincare products immediately after treatment.

  5. Results: While you may notice some immediate improvement in skin hydration and texture, the full effects of Profhilo typically develop gradually over several weeks as the hyaluronic acid in the treatment stimulates collagen and elastin production in your skin. 

  6. Maintenance: Profhilo is not a permanent treatment, so you may need maintenance sessions every six to twelve months to sustain the results. Your practitioner can advise you on the best schedule for follow-up treatments based on your individual response to the treatment and your aesthetic goals.

Frequently Asked Questions About Profhilo

  • Profhilo is suitable for individuals who want to improve skin hydration, firmness, and overall quality. It’s suitable for a wide range of skin types and ages.

Results from Profhilo treatment typically start to become noticeable after a few weeks as collagen and elastin production increases. Full results are usually seen after two treatment sessions spaced about a month apart.

Results from Profhilo can last for about six to twelve months, depending on individual factors such as skin type, lifestyle, and the quality of the skin.

Lasers are commonly used to treat facial hyperpigmentation such as freckles, melasma and sun spots.

When combining laser treatments with Profhilo treatment, we would do the laser treatment first with a mandatory skin cooling thereafter, before your Profhilo treatment. This ensures that excess heat produced by the laser does not compromise the product.

Generally, you may not be a suitable candidate for Profhilo if you have one of the following:

  • Active skin infection
  • Active skin inflammation
  • Anti-coagulant medication
  • Pregnancy/ Breastfeeding
  • Recent filler injection
  • Active autoimmune disease
  • Allergy to hyaluronic acid fillers

While Profhilo treatment helps to rejuvenate the skin, it cannot address all your skin care issues. Botulinum injections are still the gold standard for dynamic wrinkles affecting the forehead, frown lines and Crow’s Feet.

We recommend doing the Botulinum toxin treatment first, then the Profhilo treatment 2-4 weeks later so that the effects are stabilized.

A consultation is necessary before any treatment. We would need to explore what type Filler injection you had, and when it was given.

Although Profhilo is biocompatible, BDDE-free and does not contain chemical cross-linked agents, we are of the opinion that there must be a gap of at least 4 weeks from your last filler treatment.

The current indication is for the lower two-thirds of the face and neck for skin rejuvenation. 

There are case studies of doctors using Profhilo either as monotherapy or combination therapy for atrophic scars, facial acne scars and post surgical scars on the lower limbs. There are also preliminary reports of Profhilo as a complementary therapy for the management of atopic dermatitis. These results although encouraging are considered off-label for the moment.

Pain and discomfort are minimal because we use numbing cream before your treatment.

After injection, a transient swelling at the Bio-Aesthetic-Points will fade within a day. Some individuals experience mild itchiness that is temporary. As with all injectable treatments, there may be bruising that can take up to 1-2 weeks to fade.

The average cost of your Profhilo treatment is from $1000-$1200 per session.

Dr Moses Ng dermatologist

Profhilo Singapore

Prohilo is a hybrid complex of hyaluronic acid that exerts a bio-regenerating effect on the epidermis with remodelling action. It is particularly effective in my practice to counteract the effects of aging in the cheeks, chin and jawline, improving skin laxity and hydration with long lasting results.

Schedule a consultation for profhilo treatment in singapore

When you love how you look, it is easy to live your best life. Profhilo has helped countless patients restore and maintain a more vibrant and refreshed facial appearance. To find out if this cosmetic injectable is right for you, contact our clinic to arrange a consultation. Dr. Ng is exceptionally qualified to evaluate and correct your cosmetic concerns with Profhilo and other non-surgical treatments, and he looks forward to exceeding your expectations.


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Or give us a call at +65 6769 6007 | WhatsApp us +65 9855 3022

  1. Stellavato A, Corsuto L, D’Agostino A, La Gatta A, Diana P, Bernini P, et al. (2016) Hyaluronan Hybrid Cooperative Complexes as a Novel Frontier for Cellular Bioprocesses Re-Activation. PLoS ONE 11(10): e0163510.
  2. D’Agostino A, Stellavato A, Busico T, Papa A, Tirino V, Papaccio G, et al. In vitro analysis of the effects on wound healing of high- and low-molecular weight chains of hyaluronan and their hybrid H-HA/L-HA complexes. BMC Cell Biol. 2015;11;16:19.
  3. Laurino C, Palmieri B, Coacci A. Efficacy, Safety, and Tolerance of a New Injection Technique for High- and Low-Molecular-Weight Hyaluronic Acid Hybrid Complexes. Eplasty. 2015;8;15:e46.
  4. Stellavato A, La Noce M, Corsuto L, Pirozzi A, V, A, De Rosa M, Papaccio G, Schiraldi C, Tirino V: Hybrid Complexes of High and Low Molecular Weight Hyaluronans Highly Enhance HASCs Differentiation: Implication for Facial Bioremodelling. Cell Physiol Biochem 2017;44:1078-1092.