Steatocystoma Multiplex
Steatocystoma multiplex is an uncommon skin condition characterised by the development of multiple benign cysts arising from the sebaceous glands. Although the condition is not dangerous, its visible and sometimes widespread nature can cause physical discomfort, cosmetic concern and emotional distress for affected individuals.
The condition was first described in the late nineteenth century and remains relatively rare. It is distinct from more common skin cysts, such as epidermoid cysts, as steatocystoma multiplex originates from the sebaceous duct rather than the surface layers of the skin. The cysts often persist over time and may increase in number, which is why medical assessment is usually recommended.
At APAX Medical & Aesthetic Clinic, assessment focuses on confirming the diagnosis, excluding similar skin conditions and advising on appropriate management based on the extent and behaviour of the cysts.

What is steatocystoma multiplex?
Steatocystoma multiplex is a rare genetic skin disorder marked by the presence of multiple sebaceous cysts [1]. These cysts typically develop during adolescence or early adulthood, a period associated with increased sebaceous gland activity. The condition is usually inherited in an autosomal dominant pattern, although sporadic cases can also occur.
The cysts are non-cancerous and contain an oily or creamy substance derived from sebum. They commonly appear on areas of the body with a higher concentration of sebaceous glands, such as the chest, underarms, neck, abdomen, upper arms and groin. In some individuals, lesions may also occur on the face or scalp.
While the cysts are often painless, they can become inflamed, infected, or tender, particularly if they rupture or are repeatedly irritated. Steatocystoma multiplex does not resolve on its own, and management focuses on reducing symptoms, improving appearance and addressing complications when they arise.
What causes steatocystoma multiplex?
Steatocystoma multiplex develops due to abnormalities in the sebaceous glands, which are responsible for producing sebum. The condition most commonly becomes apparent during adolescence or early adulthood, when sebaceous gland activity increases.
Known causes and contributing factors include:
- Genetic mutation — In many cases, steatocystoma multiplex is linked to mutations in the KRT17 gene, which plays a role in the normal structure and function of the sebaceous glands, hair follicles and nail bed [2].
- Inherited tendency — The condition can be inherited in an autosomal dominant pattern, meaning a single altered gene from one parent can be sufficient to cause the disorder [3]. However, not all affected individuals have a family history.
- Sporadic occurrence — Some people develop steatocystoma multiplex without any known genetic or family background [4]. These sporadic cases are well recognised.
- Hormonal influence — The onset around puberty suggests that hormonal changes, particularly those affecting sebaceous gland activity, may contribute to cyst formation in susceptible individuals.
What does steatocystoma multiplex look like?
Steatocystoma multiplex usually appears as multiple small, smooth lumps beneath the skin. The cysts tend to develop gradually and may increase in number over time.
Typical features include:
- Small, round or oval cysts — The cysts are usually a few millimetres to a few centimetres in size and have a smooth surface.
- Skin-coloured to yellowish appearance — They often match the surrounding skin tone or appear slightly yellow due to their sebaceous content.
- Soft to firm texture — Most cysts feel soft or rubbery when touched, though some may feel firmer.
- Clusters in specific body areas — Common sites include the chest, armpits, neck, upper arms, abdomen, groin and occasionally the face or scalp.
- Generally painless — The cysts are usually not painful unless they become inflamed, infected or rupture.
- Possible oily discharge if ruptured — If a cyst breaks open, it may release an oily or creamy substance derived from sebum.
Although the cysts are benign, their number, location or visibility can cause concern, which is why professional assessment is often sought.

Is steatocystoma multiplex contagious or dangerous?
Steatocystoma multiplex is not contagious and cannot be spread through skin contact, shared items, or close physical interaction [5]. It is a benign condition that arises from abnormalities within the sebaceous glands and is unrelated to infection. The cysts are also not cancerous and do not increase the risk of skin cancer or other serious medical conditions.
While the condition is medically harmless, some cysts may become inflamed or infected, which can cause discomfort or tenderness. In many cases, concern relates more to appearance or long-term persistence rather than physical danger, which is why professional assessment is often sought for reassurance and appropriate management.
How is steatocystoma multiplex different from other skin cysts?
Several skin conditions can appear similar at first glance, which often leads to confusion and self-misdiagnosis. Steatocystoma multiplex has distinct clinical features that set it apart from more common cystic skin conditions. Accurate diagnosis is important, as management and expectations differ depending on the underlying cause.
| Feature | Steatocystoma multiplex | Epidermoid (sebaceous) cysts | Acne cysts |
| Cause | Developmental abnormality of the sebaceous duct, often linked to genetic factors | Blockage of hair follicles and accumulation of keratin | Inflammation of hair follicles associated with acne |
| Number of lesions | Multiple cysts, often clustered | Usually solitary or few | Multiple inflammatory lesions |
| Age of onset | Adolescence or early adulthood | Any age, more common in adults | Adolescence and young adulthood |
| Appearance | Smooth, skin-coloured to yellowish cysts | Firm, dome-shaped lumps, often with a central punctum | Red, swollen and inflamed nodules |
| Contents | Oily or creamy sebum | Thick, keratinous material | Pus and inflammatory debris |
| Pain or inflammation | Usually painless unless inflamed or infected | Usually painless unless infected | Often painful and tender |
| Resolution without treatment | Does not resolve on its own | May remain stable or slowly enlarge | May improve with acne treatment |
How is steatocystoma multiplex diagnosed?
Diagnosis is usually straightforward and based on clinical assessment, supported by additional tests when necessary to confirm the condition or rule out similar skin disorders.
Common diagnostic methods include:
- Clinical examination — A doctor assesses the appearance, distribution and texture of the cysts, which often have characteristic features suggestive of steatocystoma multiplex.
- Medical history review — Information about age of onset, progression, symptoms and any family history of similar lesions helps support the diagnosis.
- Skin biopsy (when needed) — A small tissue sample may be taken for microscopic examination. Typical findings include a cyst lined by stratified squamous epithelium with associated sebaceous glands.
- Genetic testing (select cases) — Testing for KRT17 gene mutations may be considered in atypical cases or when confirmation is required, though it is not routinely necessary for diagnosis.
When should treatment for steatocystoma multiplex be considered?
Treatment for steatocystoma multiplex is not always required, particularly when the cysts are small, stable, and not causing symptoms. In many cases, confirmation of the diagnosis and reassurance may be sufficient.
Treatment for steatocystoma multiplex may be considered in the following situations:
- When cysts continue to develop or gradually enlarge over time.
- When cysts become repeatedly swollen, tender or infected.
- When lesions cause pain, friction or discomfort, especially in areas such as the underarms or groin.
- When cysts break open and release oily material, leading to irritation or secondary infection.
- When the appearance of multiple visible cysts affects confidence or quality of life.
A medical assessment helps determine whether treatment is appropriate and which option best suits the extent of steatocystoma multiplex and individual concerns.
Treatment Options for Steatocystoma Multiplex
Treatment for steatocystoma multiplex focuses on managing symptoms, reducing visible cysts, and addressing inflammation or infection when present. As the condition is chronic and cysts can recur, no single treatment permanently prevents new cyst formation. The choice of treatment depends on the number of cysts, their location, symptoms, and individual concerns.
Medical treatments
Medications have a limited role in treating steatocystoma multiplex and are not curative.
- Oral isotretinoin — Isotretinoin may reduce inflammation and slow the formation of new cysts in some individuals by decreasing sebaceous gland activity [6]. However, responses are variable, cysts often persist and recurrence after stopping treatment is common. It is not routinely used as a standalone treatment.
- Antibiotics (short term) — Oral or topical antibiotics may be prescribed if cysts become infected or inflamed, but they do not remove existing cysts [7].
Minimally invasive procedures
These methods may provide temporary improvement but do not remove the cyst wall, which increases the risk of recurrence.
- Aspiration — A sterile needle is used to drain the cyst contents [8]. While this can flatten the cyst temporarily, the cyst lining remains in the skin, making recurrence likely.
- Incision and drainage — A small cut allows the cyst contents to be released. This approach is usually reserved for inflamed or infected cysts and is not recommended as a definitive treatment due to high recurrence rates [9].

Surgical and procedural options
Procedural treatments aim to remove the cyst wall and are generally more effective for long-term control of visible lesions.
- Modified incision techniques — Small incisions are made under local anaesthesia to allow careful removal of the cyst wall [10]. When performed properly, this reduces the risk of recurrence and helps minimise scarring. The incision is usually small and placed along natural skin lines.
- Laser treatment — Carbon dioxide (CO₂) laser may be used to treat multiple superficial cysts [11]. While it can improve appearance and reduce lesion count, complete removal of the cyst wall may not always be achieved and recurrence can still occur.
Outcomes and Long-Term Management of Steatocystoma Multiplex
- Chronic condition — Steatocystoma multiplex is benign but long-standing. New cysts may develop over time, even after treatment.
- Ongoing monitoring — Follow-up may be advised to manage recurrences, monitor for infection and address new or symptomatic cysts.
Psychosocial Impact
- Quality of life considerations — Multiple visible cysts can affect self-esteem and social confidence, particularly when lesions are widespread or located on exposed areas.
- Support and reassurance — Clear explanation of the condition, realistic expectations of treatment and supportive care play an important role in overall management.
Summary
Steatocystoma multiplex is a rare, benign skin condition characterised by the development of multiple sebaceous cysts that often appear from adolescence onwards and tend to persist over time. While the condition is not contagious or dangerous, the cysts may increase in number, become inflamed or cause physical and cosmetic concern, which is why accurate diagnosis is important to distinguish it from other skin cysts such as epidermoid cysts or acne-related lesions. Management depends on the extent of the condition, symptoms and individual priorities, with treatment options focusing on reducing visible cysts, addressing inflammation and improving comfort rather than offering a permanent cure.
If you are concerned about steatocystoma multiplex or persistent skin cysts, you may schedule a consultation with APAX Medical & Aesthetic Clinic for a detailed assessment and personalised management plan.
Frequently Asked Questions
Can steatocystoma multiplex go away on its own?
Steatocystoma multiplex does not resolve spontaneously, and the cysts usually persist once they develop. Some may remain stable, while others gradually increase in number over time.
Is steatocystoma multiplex permanent?
Steatocystoma multiplex is a long-term condition, as new cysts can continue to form even after treatment. Management focuses on symptom control and cosmetic improvement rather than permanent eradication.
Can steatocystoma multiplex worsen over time?
Steatocystoma multiplex may worsen gradually, particularly during early adulthood when sebaceous gland activity is higher. Progression varies between individuals.
Does steatocystoma multiplex affect only the skin?
Steatocystoma multiplex affects the sebaceous glands within the skin and does not involve internal organs. It is a dermatological condition only.
Can steatocystoma multiplex leave scars after treatment?
Treatment for steatocystoma multiplex may carry a small risk of scarring, depending on the method used and the location of the cysts. Careful technique helps minimise this risk.
Is steatocystoma multiplex related to poor hygiene?
Steatocystoma multiplex is not caused by poor hygiene and cannot be prevented through cleansing or skincare alone. It develops due to structural abnormalities of the sebaceous glands.
Can steatocystoma multiplex be treated all at once?
When steatocystoma multiplex is widespread, treatment is often performed in stages rather than all at once. This allows safer healing and better cosmetic outcomes.
Is steatocystoma multiplex common in Singapore?
Steatocystoma multiplex is considered rare worldwide, including in Singapore. Many cases are under-recognised or mistaken for other types of skin cysts.
Is steatocystoma multiplex life-threatening?
Steatocystoma multiplex is not life-threatening and does not increase the risk of serious illness or cancer. It is a benign skin condition that affects the sebaceous glands only.
Can steatocystoma multiplex come back after treatment?
Steatocystoma multiplex can recur after treatment, as new cysts may form over time. Recurrence depends on the treatment method and individual skin behaviour.
Can lifestyle changes help with steatocystoma multiplex?
Lifestyle changes cannot cure steatocystoma multiplex, as it is not caused by diet or hygiene. Good skin care may help reduce irritation but does not prevent cyst formation.
What should I do if cysts from steatocystoma multiplex become painful or infected?
Painful or infected cysts from steatocystoma multiplex should be medically assessed to reduce inflammation and prevent complications. Treatment may be needed to manage infection and relieve discomfort.
Does steatocystoma multiplex require long-term follow-up?
Follow-up for steatocystoma multiplex may be advised to monitor recurrence, manage new cysts or address inflammation when it occurs.
Can steatocystoma multiplex be inherited by family members?
Steatocystoma multiplex can run in families, though not all affected individuals have a known family history. Genetic inheritance patterns vary.

Steatocystoma Multiplex
Steatocystoma multiplex is a chronic genetic disorder characterized by multiple sebaceous cysts. While there is no cure, various treatments can manage symptoms and improve the quality of life for affected individuals. Regular dermatological care and support can help navigate the challenges posed by the condition.
Dr. Moses Ng
Schedule a consultation for Steatocystoma Multiplex removal in singapore
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If you have any questions or would like to schedule a consultation to discuss steatocystoma multiplex removal, please do not hesitate to contact our office.
References
- Kamra, H. T., Gadgil, P. A., Ovhal, A. G., & Narkhede, R. R. (2013). Steatocystoma multiplex-a rare genetic disorder: A case report and review of the literature. Journal of Clinical and Diagnostic Research : JCDR, 7(1), 166–168. https://doi.org/10.7860/JCDR/2012/4691.2698
- LIU, Q., WU, W., LU, J., WANG, P., & QIAO, F. (2015). Steatocystoma multiplex is associated with the R94C mutation in the KRTl7 gene. Molecular Medicine Reports, 12(4), 5072–5076. https://doi.org/10.3892/mmr.2015.4063
- Georgakopoulos, J. R., Ighani, A., & Yeung, J. (2018). Numerous asymptomatic dermal cysts: Diagnosis and treatment of steatocystoma multiplex. Canadian Family Physician, 64(12), 892–899. https://www.cfp.ca/content/64/12/892
- Shin, N.-Y., Kang, J. H., Kim, J.-E., Symkhampa, K., Huh, K.-H., Yi, W.-J., Heo, M.-S., Lee, S.-S., & Choi, S.-C. (2019). Steatocystoma multiplex: A case report of a rare entity. Imaging Science in Dentistry, 49(4), 317–321. https://doi.org/10.5624/isd.2019.49.4.317
- Fekete, G. L., & Fekete, J. E. (2010). Steatocystoma multiplex generalisata partially suppurativa—Case report. Acta Dermatovenerologica Croatica: ADC, 18(2), 114–119.
- Apaydin, R., Bilen, N., Bayramgürler, D., Başdaş, F., Harova, G., & Dökmeci, S. (2000). Steatocystoma multiplex suppurativum: Oral isotretinoin treatment combined with cryotherapy. The Australasian Journal of Dermatology, 41(2), 98–100. https://doi.org/10.1046/j.1440-0960.2000.00403.x
- AlSabbagh, M. M. (2016). Steatocystoma multiplex: A review. Journal of Dermatology & Dermatologic Surgery, 20(2), 91–99. https://doi.org/10.1016/j.jdds.2016.02.001
- Park, S. Y., Lee, H. J., Jung, Y. J., & Choi, E. H. (2012). A case of steatocystoma multiplex treated with combination of needle aspiration and trichloracetic acid. Korean Journal of Dermatology, 50(7), 644–646. https://www.scopus.com/pages/publications/84865395901
- Palaniappan, V., & Karthikeyan, K. (2023). Steatocystoma multiplex. Indian Dermatology Online Journal, 15(1), 105–112. https://doi.org/10.4103/idoj.idoj_490_23
- Choudhary, S., Koley, S., & Salodkar, A. (2010). A modified surgical technique for steatocystoma multiplex. Journal of Cutaneous and Aesthetic Surgery, 3(1), 25–28. https://doi.org/10.4103/0974-2077.63284
- Rossi, R., Cappugi, P., Battini, M., Mavilia, L., & Campolmi, P. (2003). CO2 laser therapy in a case of steatocystoma multiplex with prominent nodules on the face and neck. International Journal of Dermatology, 42(4), 302–304. https://doi.org/10.1046/j.1365-4362.2003.01309.x











