Aklief Trifarotene Acne Cream

trifarotene back acne treatment

AKLIEF Trifarotene Acne Cream

Clincially proven acne treatment for face, chest, shoulders, back.

Get Back To Clearer Skin

aklief trifatotene acne cream

The Latest 4th Generation Retinoid

AKLIEF Trifarotene Acne Cream is a new first fourth-generation retinoid for the treatment of facial and truncal acne. It is approved for use from 9 years of age and older. Visible differences can be seen in as little as 2 weeks of treatment. Most patients do not report any side effects when using trifarotene (Aklief) cream.

Hidden Burden of Back Acne

For many years, much focus had been placed on facial acne management because what is thought to be most visible would also be most troubling to the individual. However, recent studies have indicated that individuals with both facial and truncal acne have 1.5 times more impact on their quality of life than those with facial acne alone. The impact of back acne regardless of facial acne can lead to profound fear of wearing certain clothes in public, refraining from participation in activities such as swimming, going to the beach or to the sauna. The psycho-social impact of back acne cannot be underestimated when almost 50% of patients with facial acne also have truncal acne. Having truncal acne can negatively impact intimate relationships and reduce physical attractiveness. 

back acne treatment
Truncal or Back Acne

What is Aklief Trifarotene Acne Cream?

Trifarotene (Aklief) cream is a 4th generation retinoid that is effective for face, chest, shoulder and back acne. Trifarotene acne treatment exerts more targeted skin-specific changes that influences skin keratinazation, inflammation and hyperproliferation compared to older generation retinoids (e.g. tretinoin, adapalene).

rar gamma molecule trifatotene
Targeting the RAR-γ reduces inflammation and normalizes skin growth

How Does Aklief Trifarotene Acne Cream Work?

Retinoids, which are Vitamin A derivative agents, have been used is the management of acne for decades. They exert their effects on retinoid receptors found in the nucleus of human skin cells. There are 3 major types of retinoic acid receptors (RAR) in the skin; alpha, beta and gamma. RAR-gamma or RAR-γ are the most abundantly found retinoic acid receptors in the epidermis of the human skin.

Trifarotene works by specifically targeting RAR-γ, the most common retinoic acid receptor in the skin. With 20 times greater affinity for RAR-γ, trifarotene leads to more specific changes to improvement in comedomes, inflammation and hyperpigmentation.

Moreover, trifarotene improves skin hydration by strengthening the skin barrier and also reduces proteins that degrade elastin and collagen, thus protecting the skin against aging.

Reduces Inflammation

Specific trageting of RAR-γ to modulate immune response and inflammation within your skin

Speeds Skin Cell-Turnover

Reduces plugging and comedomes within the hair follicles to allow new skin cells to form

Improves Skin Hydration

Strengthening the skin barrier by inducing more water channels in the skin

Reduces Hyperpigmentation

Trifarotene improves hyperpigmentation that is common with acne and has anti-aging effects

How Effective Is It?

Being specific to target the RAR-gamma, only a small percentage of the active ingredient, 0.005%, is effective at treating acne. Clinical studies have shown improvement on acne from as little as 2 weeks. In individuals with inflammatory truncal acne, 36% achieved clear or almost clear skin in 12 weeks, whereas almost 30% of those with facial acne achieved similar results. Research has also shown that long-term use of trifarotene cream is safe and effective even when using for 1 year duration. Click here to see results.

Fast Results. Powerful Action. Excellent Tolerability.

Proven clinical efficacy in clinical trials involving more than 2000 patients.

Who Is Suitable For Aklief Trifarotene Acne Cream treatment?

Trifarotene is the first fourth-generation retinoid for facial and/or truncal acne for individuals from 9 years of age or older.

What are the side effects of Trifarotene?

As trifarotene selectively acts on the RAR-γ receptors on the skin, it is generally well tolerated.  As with topical retinoid therapy, you may experience some dryness, redness, itchiness and peeling during the first few weeks of application. However, these side effects are generally mild in nature and will gradually subside over time. 

During the course of your treatment with trifarotene, you should remember to minimize exposure to ultraviolet light to reduce sunburns and skin irritation. 

When should you Not Use Aklief Trifarotene acne cream.

  • Avoid using trifarotene cream to open wounds, cuts, eczematous or sunburned skin. 
  • Avoid using medicated or abrasive cleansers, skin care products that have strong drying effects and/or contain high concentration of alcohol
  • Avoid of ‘waxing’ for hair removal while using topical trifarotene face and back acne treatment

Tips for using topical retinoids:

  • Use moisturizer before and after application of the topical retinoid
  • Gradual use – avoid using daily for the first few weeks
  • Short contact therapy for 30mins and then washing off is effective for those who are easily irritated with topical retinoids
  • Intermittent use may be beneficial for those unable to tolerate daily application.


The targeted mechanism of trifarotene allows it to effectively treat acne while minimising potential side effects. The main advantage of trifarotene cream is its use in treatment of both inflammatory and non-inflammatory lesions. Treatment of early acne has been shown to reduce acne progression and scarring. Although it has been approved for the treatment of acne vulgaris, future applications may include folliculitis, acanthosis nigricans, hyperpigmentation and melasma.

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  1. Tan J, Thiboutot D, Popp G, Gooderham M, Lynde C, Del Rosso J, Weiss J, Blume-Peytavi U, Weglovska J, Johnson S, Parish L. Randomized phase 3 evaluation of trifarotene 50 μg/g cream treatment of moderate facial and truncal acne. Journal of the American Academy of Dermatology. 2019 Jun 1;80(6):1691-9.
  2. Blume‐Peytavi U, Fowler J, Kemény L, Draelos Z, Cook‐Bolden F, Dirschka T, Eichenfield L, Graeber M, Ahmad F, Alió Saenz A, Rich P. Long‐term safety and efficacy of trifarotene 50 μg/g cream, a first‐in‐class RAR‐γ selective topical retinoid, in patients with moderate facial and truncal acne. Journal of the European Academy of Dermatology and Venereology. 2020 Jan;34(1):166-73.
  3. Aubert J, Piwnica D, Bertino B, Blanchet‐Réthoré S, Carlavan I, Déret S, Dreno B, Gamboa B, Jomard A, Luzy AP, Mauvais P. Nonclinical and human pharmacology of the potent and selective topical retinoic acid receptor‐γ agonist trifarotene. British Journal of Dermatology. 2018 Aug 1;179(2):442-56.

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