AKLIEF Trifarotene Acne Cream is a new first fourth-generation retinoid for the treatment of facial and truncal acne. It is approved for use from 9 years of age and older. Visible differences can be seen in as little as 2 weeks of treatment. Most patients do not report any side effects when using trifarotene (Aklief) cream.
For many years, much focus had been placed on facial acne management because what is thought to be most visible would also be most troubling to the individual. However, recent studies have indicated that individuals with both facial and truncal acne have 1.5 times more impact on their quality of life than those with facial acne alone. The impact of back acne regardless of facial acne can lead to profound fear of wearing certain clothes in public, refraining from participation in activities such as swimming, going to the beach or to the sauna. The psycho-social impact of back acne cannot be underestimated when almost 50% of patients with facial acne also have truncal acne. Having truncal acne can negatively impact intimate relationships and reduce physical attractiveness.
Trifarotene (Aklief) cream is a 4th generation retinoid that is effective for face, chest, shoulder and back acne. Trifarotene acne treatment exerts more targeted skin-specific changes that influences skin keratinazation, inflammation and hyperproliferation compared to older generation retinoids (e.g. tretinoin, adapalene).
Retinoids, which are Vitamin A derivative agents, have been used is the management of acne for decades. They exert their effects on retinoid receptors found in the nucleus of human skin cells. There are 3 major types of retinoic acid receptors (RAR) in the skin; alpha, beta and gamma. RAR-gamma or RAR-γ are the most abundantly found retinoic acid receptors in the epidermis of the human skin.
Trifarotene works by specifically targeting RAR-γ, the most common retinoic acid receptor in the skin. With 20 times greater affinity for RAR-γ, trifarotene leads to more specific changes to improvement in comedomes, inflammation and hyperpigmentation.
Moreover, trifarotene improves skin hydration by strengthening the skin barrier and also reduces proteins that degrade elastin and collagen, thus protecting the skin against aging.
Specific trageting of RAR-γ to modulate immune response and inflammation within your skin
Reduces plugging and comedomes within the hair follicles to allow new skin cells to form
Strengthening the skin barrier by inducing more water channels in the skin
Trifarotene improves hyperpigmentation that is common with acne and has anti-aging effects
Being specific to target the RAR-gamma, only a small percentage of the active ingredient, 0.005%, is effective at treating acne. Clinical studies have shown improvement on acne from as little as 2 weeks. In individuals with inflammatory truncal acne, 36% achieved clear or almost clear skin in 12 weeks, whereas almost 30% of those with facial acne achieved similar results. Research has also shown that long-term use of trifarotene cream is safe and effective even when using for 1 year duration. Click here to see results.
Proven clinical efficacy in clinical trials involving more than 2000 patients.
Trifarotene is the first fourth-generation retinoid for facial and/or truncal acne for individuals from 9 years of age or older.
As trifarotene selectively acts on the RAR-γ receptors on the skin, it is generally well tolerated. As with topical retinoid therapy, you may experience some dryness, redness, itchiness and peeling during the first few weeks of application. However, these side effects are generally mild in nature and will gradually subside over time.
During the course of your treatment with trifarotene, you should remember to minimize exposure to ultraviolet light to reduce sunburns and skin irritation.
The targeted mechanism of trifarotene allows it to effectively treat acne while minimising potential side effects. The main advantage of trifarotene cream is its use in treatment of both inflammatory and non-inflammatory lesions. Treatment of early acne has been shown to reduce acne progression and scarring. Although it has been approved for the treatment of acne vulgaris, future applications may include folliculitis, acanthosis nigricans, hyperpigmentation and melasma.
Dr. Moses Ng is a distinguished professional in the field of aesthetic medicine, renowned for his expertise in advanced cosmetic procedures. With over 15 years of experience, extensive training and a keen eye for detail, Dr. Ng specializes in a wide range of treatments, including injectables, laser therapies, and acne scar management.
Dr. Moses Ng’s commitment to excellence and patient-centric approach have earned him a reputation as a trusted clinician in aesthetic medicine. His continuous pursuit of the latest advancements in the field ensures that his patients receive the highest standard of care and the most effective treatments available.
